15-JUL-2024 6:10

Lung-MAP ACCRUAL REPORT

  O
P
E
N		 ACCR
GOAL		 TOTAL
REGS.		 REGS.
LAST
12
Month		 REGS.
LAST
6
Month		 REGS.
LAST
3
Month		 REGS.
LAST
30
DAYS		 REGS.
LAST
7
DAYS		 DATE OF
FIRST
REG.		 # of
ACT.
INSTs		 # of
CURR
IRBs
LUNGMAP Screening Protocol Registrations
Total     3420 313 158 76 28 9 02/06/2019 424 178
Screened at PD     1210 71 30 12 1 0      
Pre-Screened prior to PD     2210 242 128 64 27 9      
ctDNA Specimen Submission     315 0 0 0 0 0      
Re-analysis Requests     459 106 50 24 11 2      
 
Sub-Study Assignments
LUNGMAP Sub-Study Assignments     1727 58 25 12 3 0      
Screened at PD     978 35 15 6 2 0      
Pre-Screened prior to PD     697 23 10 6 1 0      
After PD on a Lung_MAP Sub-Study     52 0 0 0 0 0      
 
Sub-Study Assignments (open studies only)
S1900E     239 38 15 8 2 0      
S1900G     20 17 7 3 1 0      
S1900K     3 3 3 1 0 0      
 
Sub-Study Registrations
LUNGMAP Sub-Study Registrations     484 31 11 5 3 0      
Initial sub-study registrations     472 31 11 5 3 0      
Subsequent sub-study registrations     12 0 0 0 0 0      
 
Patients Registered to a Sub-Study (open studies only)
S1900E: KRAS G12C: Sotorasib (AMG 510)   116 115 20 6 3 2 0 04/16/2021 320 127
Cohort 1: TP53 N   48 6 0 0 0 0      
Cohort 2: STK11 Y   28 8 4 2 1 0      
Cohort 3: All Others Y   39 6 2 1 1 0      
S1900G: EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu   66 13 11 5 2 1 0 05/05/2023 264 100
Capmatinib + Osimertinib + Ramucirumab Y   6 5 3 2 1 0      
Capmatinib + Osimertinib Y   7 6 2 0 0 0      
 

15-JUL-2024 6:10

Lung-MAP Open Studies with No Registrations

Study Registration/Phase Open Date # of
ACT.
INSTs		 # of
CURR
IRBs
S1900K MET Exon 14: Tepotinib +/- Ramucirumab 1 Randomization 18-Dec-23 217 84